Set in an alternative world where aliens have come to Earth and integrated with society, LaGuardia revolves around a pregnant Nigerian-American doctor, Future Nwafor Chukwuebuka who has just returned to NYC under mysterious conditions. After smuggling an illegal alien plant named "Letme Live" through LaGuardia International and Interstellar Airport's customs and security, she arrives at her grandmother's tenement, the New Hope Apartments in the South Bronx.
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